I did this with Qubes a year ago and haven’t had any issues apart from figuring out the right flags to get the full performance, otherwise the GPU would cap around 30% under load with low CPU load.

Kind of at the mercy of what your motherboard and bios will allow, mine I had to cheese a little and disable the PCI device on boot so I get to decrypt my disk with no screen lol but it works!

Not op but I do a lot of architecture and infrastructure work on top of my normal dev work so keeping everything separated and per-client has become a pretty important advantage for me personally

Fwiw I had to tinker a bit to get good video playback, Fedora was always choppy for me for some reason but debian is typically smooth with hw accel disabled.

As for the gaming, depending on your setup (I have a desktop and T480 I keep in sync) you can absolutely run two video cards and do PCI passthrough on one to a gaming VM. I have mine set up with a dedicated NIC and USB card and just use a KVM to swap between Qubes and Windows (for now) and it’s worked really well. Had to play around a ton to get the full speed out of the GPU though and it only seemed to work in windows so hopefully get that going for a Linux hvm one day.

Absolutely agree there is no going back, I have all of my work stuff entirely hardware agnostic and a full on replica of my work desktop ready to go in a moment should the desktop die. Apart from that keeping client work isolated has been such a game changer.

Fwiw I used to daily an x210 and then an x230 in IT and pretty frequently typed with one hand while carrying with another without the weight bugging me but your mileage may vary.

You can definitely send them flying and not damage them my coworker launched theirs across the office and the bezel just snapped back together.

I have a T480 now since I do more dev work and needed a slightly bigger keyboard/screen and it’s phenomenal with Qubes and 48gb of memory on the quad core i5. Love the ease to repair I just swapped a motherboard on it in around 30 minutes and was back up and running

I just use nextcloud as a target for backups (Aegis, Signal, QkSMS). Apps such as KeePassDX I have load the file via nextcloud. My contacts and calendar go through it as well, photos are just set to auto upload along with a few other directories.

As for the home screen layouts, I just take screenshots once I have it how I like and try to remember to take them again if I change stuff.

It’s not a full backup but I’m back up and running fairly quickly (Pixel 5A died on me 3 times in under a one year lifespan per device).